HEMOSTATIC AND HEMATOLOGICAL STUDIES OF AQUEOUS EXTRACT OF BIDENS PILOSA IN WISTAR RATS

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HEMOSTATIC AND HEMATOLOGICAL STUDIES OF AQUEOUS EXTRACT OF BIDENS PILOSA IN WISTAR RATS

ABSTRACT

Bidens pilosa L. (Asteraceae) also known as hairy beggar ticks, common names include; ‘Ogwunma’; ‘Gyeya'(Igbo, Birom, Nigeria) and is one of the medicinal plant species worldwide. Among the Birom tribes in Plateau State, Nigeria Bidens pilosa is used as vegetable to prepare the local delicacy called ghote and also the sap from crushed leaves is used to speed up clotting of blood in fresh wounds. The aim of the study was to evaluate the effect of aqueous extract of Bidens pilosa leaves on selected haemostatic and haematological profile in Wistar rats. Phytochemical tests were carried out on Bidens pilosa leave extract (BPLE) to detect the presence of metabolites. Lorke’s method was employed for Acute Toxicity studies to determine the LD50 of the B.pilosa extract while in sub-chronic toxicity study, graded doses of BPLE ranging 200-800 mg/kg b.w and distilled water were orally administered daily for 28 days. Sample collection of rats was done prior to administration of extract (Day 0) for base line studies and on days 14 and 28 for evaluation and monitoring of the effect of the aqueous extract of B.Pilosa on some selected haemostatic and haematological profile. The haemostatic profile was determined using Prothrombin Time Test(PTT),Activated Partial thromboplatin Time (APTT) and Thrombin Time Test(TT). The haematological profile was determined using Auto Haematology Analyser BC280 Vet. The BPLE was found to contain some metabolites such as flavonoids, cardiac glycosides ,saponins, tannins carbohydrates and alkaloids. No mortality was recorded during the studies in rats. Generally, significant increase at P

Evaluation Of Serum Vitamin B12 Level In Celiac Disease Patients And It’s Effect On Red Cell Parameters

ALLA ABDALLAH BASHIR MOHAMMAD 56 PAGES (8948 WORDS) MEDICAL LAB SCIENCE AND TECH DISSERTATION

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Abstract

Celiac disease is one of the most common lifelong disorders. It is genetic autoimmune disorder occur when the ingestion of gluten leads to damage in the small intestine. Vitamin B12 malabsorption are common in celiac disease as the proximal small intestine is predominantly affected. We aimed to study serum vitamin B12 levels in celiac disease patients.

This was a cross sectional study, conducted, to estimate the serum levels of vitamin B12 among 40 Sudanese patients with celiac disease; their age range from 2-43 years .Ten (25%) of the patients were males and 30 (75%) were females; all were diagnosed by serological test and endoscopy and referred at Ibn Sinaa hospital, in the period from April to Augest 2016. About 3 ml of venous blood sample were collected by venipuncture technique from each patient, and then allowed to clot to obtain serum .The serum levels of vitamin B12 were measured using immunoassay analyzer (Cobas e411).

The result showed that, frequency of B12 deficiency among celiac disease patients were 12.5% (5/40), one (2.5%) was male and four (10%) were females. There was no statistically significant correlation between vitamin B12 deficiency and each of gender, age and duration of disease. There was statistically significant correlation between vitamin B12 deficiency and dietary program commitment (P value = 0.017). No significant correlation was found between serum B12 level and RBCs parameters. The results of this study concluded that, 12.5 % of celiac disease patients were deficient for vitamin B12 and there was statistically significant correlation between vitamin B12 deficiency and dietary program commitment.

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