SERUM GAMMA-GLUTAMYL TRANSFERASE, TOTAL ANTIOXIDANT CONCENTRATION AND HISTOLOGICAL CHANGES IN LIVER, KIDNEY AND HEART OF ALLOXANINDUCED DIABETIC RATS.

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SERUM GAMMA-GLUTAMYL TRANSFERASE, TOTAL ANTIOXIDANT CONCENTRATION AND HISTOLOGICAL CHANGES IN LIVER, KIDNEY AND HEART OF ALLOXANINDUCED DIABETIC RATS.

ABSTRACT

This study was performed to determine gamma-glutamyl transferase(GGT) and total antioxidant capacity(TAC) and examine the liver, kidney, heart changes in alloxan-induced diabetes. 40 wistar rats of both sexes weighing between 160g-210g were divided into two groups A (control) and B (diabetic) consisting of 20 rats each. Group A received normal saline while group B were given a single dose of alloxan monohydrate at 150mg/kg body weight intraperitoneally. On 3rd and 5th weeks respectively, 10 rats from each group were sacrificed, blood samples collected and organs excised for biochemical and histological studies. The mean serum GGT concentration of the diabetic group at 3 and 5 weeks (4.0±0.2iu/l and 4.4±0.2iu/l respectively) were significantly higher (p

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