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SERUM FIBRONECTIN LEVELS IN PEOPLE LIVING WITH HIV/AIDS
ABSTRACT
Serum fibronectin level was investigated in people living with HIV/AIDS. A
total of 161 subjects were recruited into the study. Out of this, 98 (60.9%)
constituted the patient population while 63 (39.1%) formed the controls. The
age range considered was between 10 to 65 years. Ethical clearance was
obtained from the Health Research Ethics Committee (HREC) of University of
Nigeria Teaching Hospital, (UNTH) Ituku Ozalla. Informed consent was
obtained from the participants and questionnaires were used to collect some
vital data from them. Human fibronectin ELISA kit from WKEA Med Supplies
Corp. was used to assay for fibronectin concentration while CD4+ count was
assayed using PARTEC CD4+ easy count kit. The relationship between
fibronectin level and CD4+ count was investigated using Spearman’s
Correlation Coefficient. Test of significance for the following parameters was
conducted using the Student’s t-test and probability values less than 0.05
(p200). The effect of duration of treatment with
HAART on fibronectin level in the patient group was investigated using the
Analysis of Variance Technique (ANOVA). From the result of the study, no
correlation existed between fibronectin concentration and CD4+ count in the
patient population (r=-0.084, p=0.1911). The same holds for the control
group (r=-0.02, p=0.5931). Comparison of fibronectin level between the test
and control group showed a highly significant statistical difference (p
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