THE INVOLVEMENT OF TRANSIENT RECEPTOR POTENTIAL MELASTATIN (TRPM) MEMBER 6 AND 7 CHANNEL REGULATORY PROTEINS AND IMBALANCE OF CALCIUM AND MAGNESIUM IONS IN THE AETIOLOGY OF BEINGN PROSTATIC H

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THE INVOLVEMENT OF TRANSIENT RECEPTOR POTENTIAL MELASTATIN (TRPM) MEMBER 6 AND 7 CHANNEL REGULATORY PROTEINS AND IMBALANCE OF CALCIUM AND MAGNESIUM IONS IN THE AETIOLOGY OF BEINGN PROSTATIC H

ABSTRACT

Background: Benign prostatic hyperplasia is a well-known and commonly diagnosed urological condition in the aging male population, which affects over 50% of men in their 60s and increased to 90% by the age of 85 years. The condition is normally accompanied by lower urinary tract symptoms that impacts negatively on the quality of life. Upon all the problems that BPH cause in the life of men, the exact aetiology is unknown. Several mechanism have been mentioned that contribute to the pathogenesis of BPH but no mechanism have been proven to solely cause BPH. The role of abnormal Ca2+ and Mg2+ levels in the development of many human diseases have been documented. These studies associated the development of human diseases as a result of imbalance of Ca2+ and Mg2+ to either defect in expression of TRPM6 and TRPM7 channels or abnormal levels of ions in water and diet. A study recently has shown the existence of this calcium (Ca2+) and magnesium (Mg2+) imbalance in BPH condition however, the exact mechanism that mediates this imbalance is unknown. Aim: The aim of the study was to investigate the involvement of TRPM6 and TRPM7 channel regulatory proteins and their association with calcium (Ca2+) and magnesium (Mg2+) imbalance in the BPH patients. Method: The study was a quasi-experimental study design. Venous blood sample of 4 ml were obtained from 36 BPH patients by convenient sampling method and age matched control and prostate cancer patients were also added. The blood samples were centrifuged after clotting to get the serum. Calcium (Ca2+) and magnesium (Mg2+) concentration in the serum were then assayed using spectrophotometry. ELISA was used to determine the levels of TRPM6 and TRPM7 channel regulatory proteins in the serum. The data obtained was analysed using unpaired student t test, ANNOVA and correlation on Graphpad prisms version 6.05. Results: The calcium (Ca2+) measured in the study was high in control (2.44±0.36) followed by prostate cancer (PCa) samples (2.09±0.73) and then BPH (1.92±0.63). There was a significant difference between BPH and control (P=0.0005) and PCa and control (P=0.0466). Magnesium (Mg2+) also followed the same trend with significant difference between BPH both control (P

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