EFFECT OF CHLORINE CAFFEINE INGESTION ON SHORT TERM MEMORY, LOCOMOTION AND EXPLORATORY BEHAVIOUR IN RATS

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EFFECT OF CHLORINE CAFFEINE INGESTION ON SHORT TERM MEMORY, LOCOMOTION AND EXPLORATORY BEHAVIOUR IN RATS

CHAPTER ONE

INTRODUCTION

1.1 Background of the study

Methylxanthine caffeine, present in many common beverages, is among the psychostimulant drugs more extensively consumed by the world population. Besides having a stimulant effect on the heart and respiratory system, caffeine also presents numerous behavioral stimulant effects. It has weak reinforcing properties inducing self-administration both in humans and non-human primates. Moderate doses of caffeine induce behavioral stimulant effects that suggest CNS stimulation but higher doses can suppress behavioral activity and even performances associated with learning and memory.

There are many reports showing that caffeine may ameliorate amnesia in human beings, particularly in cases of age-related cognitive decline, scopolamine-induced amnesia (4), and electroconvulsive therapy. Many of these studies with human subjects are not specifically addressed to memory issues and interpretations of the results may be difficult due to interference of the previous caffeine consumption habits and heterogeneity of the samples. The improving effect of caffeine on animal models of learning and memory has been reported since the 1960’s (8,9) but the results of these animal studies are also contradictory. We recently published a study reporting that the effect of caffeine on two other memory tasks depends on the schedule of administration. Depending on whether it is administered pre-training or post-training it can impair or improve memory, respectively.

Statement of the problem

There may have been previous researches in this subject. This work gives further explanations and analysis in effect of chlorine caffeine ingestion on short term memory, locomotion and exploratory behaviour in rats

Objectives of the study
To understand the effect of chlorine caffeine ingestion on short term memory, locomotion and exploratory behaviour in rats
To understand the relationship between chlorine caffeine ingestion and short term memory, locomotion and exploratory behaviour in rats

Research questions
What is the effect of chlorine caffeine ingestion on short term memory, locomotion and exploratory behaviour in rats
What is the relationship between chlorine caffeine ingestion and short term memory, locomotion and exploratory behaviour in rats